铁 偲

出生年月：1986年3月

教育背景

2004–2008 北京大学化学与分子工程学院，化学 学士

2011–2012 英属哥伦比亚大学，分析化学 访问学者

2008–2013 北京大学化学与分子工程学院，分析化学 博士

工作经历

2019–今 中国矿业大学(北京)，副研究员

2015–2019 中国医学科学院药物研究所，副研究员

2013–2015 中国医学科学院药物研究所，助理研究员

研究方向

• 基于毛细管电泳/质谱联用技术（Capillary Electrophoresis/Mass spectrometry）的蛋白质表征新技术研究

  采用毛细管电泳/质谱联用接口技术建立包括大分子药物在内的各类完整蛋白的高通量、高灵敏分析方法，完成包括糖基化、糖化、乙酰化等在内的多种蛋白质翻译后修饰定性、定量检测，开展药物质控、疾病生物标志物的探索。

• 基于质谱技术的多组学联用技术研究

  基于质谱方法的开展基因组学、转录组学、蛋白组学、代谢组学等多组学分析新方法研究，开展疾病早期诊断以及预后生物标识物以及疾病新靶点发现，药物作用机理的研究。

• 基于质谱技术的环境污染物分析方法研究

  基于质谱方法开展水、土、大气中各类污染物的分析方法研究，开展环境暴露组学研究。

学术成果

    主持/参与国家自然科学基金，863计划，国家科技重大专项等多项课题。发表SCI论文20余篇，多项专利，2018年获中国分析测试协会CAIA奖一等奖。

• 近五年发表主要论文:

1. Li M, Hu T, Tie C, Qu, L, Zheng H, Zhang JL. Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney. Proteomics, 2017, 17 (22), 1700001.

2. Hu T, Tie C, Wang Z, Zhang JL. Highly Sensitive and Specific Derivatization Strategy to Profile and Quantitate Eicosanoids by UPLC-MS/MS. Analytica Chimica Acta, 2017, 15, 108-118. (Co-first author)

3. Yan XD, Wang QM, Tie C., Jin HT, et al. Polydatin protects the respiratory system from PM2.5 exposure. Sci. Rep. 2017, 7, 40030. (Co-first author)

4. Chen Z, Zhong X, Tie C, Chen B, Zhang X, Li L. Development of a hydrophilic interaction liquid chromatography coupled with matrix-assisted laser desorption/ionization-mass spectrometric imaging platform for N-glycan relative quantitation using stable-isotope labeled hydrazide reagents. Anal Bioanal Chem, 2017, 409 (18), 4437-4447.

5. Tie C, Hu T, Jia ZX, Zhang JL. Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring. Anal Chem, 2016, 88,7762-8.

6. Tie C, Hu T, Zhang JL. Novel identification strategy for ground coffee adulteration based on UPLC–HRMS oligosaccharide profiling. Food Chem, 2016, 190, 1046-1049.

7. Maclennan MS, Tie C, Kovalchik K, Peru KM, Zhang X, Headley JV, et al. Potential of capillary electrophoresis mass spectrometry for the characterization and monitoring of amine-derivatized naphthenic acids from oil sands process-affected water. Journal of Environmental Sciences, 2016, 49(11), 203-212.

8. Tie C, Hu T, Jia ZX, Zhang JL. Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Anal Chem, 2015, 87, 8181-5.

9. Tie C, Hu T, Guo B, Zhang JL. Novel strategy for herbal species classification based on UPLC-HRMS oligosaccharide profiling. J Pharm Biomed Anal, 2015, 111.

10. Zhao MZ, Tie C, Zhang YW, Deng Y, Zhang FT, Zhou YL, Zhang XX. Deuterated hydrazino-s-triazine as highly-efficient labelling reagent for glycan relative quantification analysis using electrospray ionization mass spectrometry. RSC Advances, 2015, 5 (97), 79317-79322.

11. Tie C, Hu T, Zhang XX, Zhou J, Zhang JL. HPLC-MRM relative quantification analysis of fatty acids based on a novel derivatization strategy. Analyst 2014, 139.

联系方式

    邮箱：tiecai@cumtb.edu.cn